Rational Design of Helical Nanotubes from Self-assembly of Coiled-coil Lock Washers
نویسندگان
چکیده
منابع مشابه
Rational design of helical nanotubes from self-assembly of coiled-coil lock washers.
Design of a structurally defined helical assembly is described that involves recoding of the amino acid sequence of peptide GCN4-pAA. In solution and the crystalline state, GCN4-pAA adopts a 7-helix bundle structure that resembles a supramolecular lock washer. Structurally informed mutagenesis of the sequence of GCN4-pAA afforded peptide 7HSAP1, which undergoes self-association into a nanotube ...
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ژورنال
عنوان ژورنال: Microscopy and Microanalysis
سال: 2013
ISSN: 1431-9276,1435-8115
DOI: 10.1017/s143192761300370x